Renal fibroblast-like cells in Goodpasture syndrome rats
نویسندگان
چکیده
منابع مشابه
Goodpasture syndrome.
Epidemiology Goodpasture syndrome is diagnosed in 1 in 1 million persons each year. Whites are affected more than is any other race, and the incidence is slightly higher in men than in women. The syndrome affects 2 different age groups: persons in their mid 30s and persons in their late 50s. With current therapy, survival through the acute phase is more than 90%. However, 2-year survival is les...
متن کاملEndoneurial fibroblast-like cells.
Endoneurial fibroblast-like cells (EFLCs) have been described for more than 60 years, but the embryology, functions, and pathology of these cells are not well defined. Several hypotheses of their origin have been proposed. A previous study suggesting that they were of neural crest origin is supported by our data in humans. This lineage might account for EFLCs having multiple biologic functions ...
متن کاملCellular and molecular aspects of Goodpasture syndrome.
Goodpasture syndrome, a rare human autoimmune disorder, is characterized by the presence of pathogenic autoantibodies that react with the components of the glomerular basement membrane. The clinical condition of the Goodpasture syndrome is characterized by an acute necrotizing glomerulonephritis, often with accompanying pulmonary hemorrhage. Notably, the Goodpasture antigen has been localized t...
متن کاملGenetically modified bone marrow continuously supplies anti-inflammatory cells and suppresses renal injury in mouse Goodpasture syndrome.
In chronic inflammation, macrophages and neutrophils, which are derived from bone marrow, play a pivotal role. Therefore, reconstitution of bone marrow with anti-inflammatory stem cells may modify inflammation. In this study, transplantation-based gene therapy was applied to glomerular inflammation for a long-lasting suppression of the glomerular damage seen in chronic nephritis. Bone marrow ce...
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mechanical stimuli: cyclooxygenase-2, manganese superoxide Taylor WR. Cyclic strain induces an oxidative stress in endotheldismutase, and endothelial cell nitric oxide synthase are selectial cells. Am J Physiol 1997; 272: C421-427 ively up-regulated by steady laminar shear stress. Proc Natl 34. Jun T, Ke-yan F, Catalano M. Increased superoxide anion Acad Sci USA 1996; 93: 10417-10422 production...
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ژورنال
عنوان ژورنال: Kidney International
سال: 2001
ISSN: 0085-2538
DOI: 10.1046/j.1523-1755.2001.060002597.x